Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 6, Pages 993-1007Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2008.11.016
Keywords
RAGE; S100; Surface plasmon resonance
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The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the immunoglobulin family. RAGE interacts with structurally different ligands probably through the oligomerization of the receptor on the cell surface. However, the exact mechanism is unknown. Among RAGE ligands are members of the S100 protein family. S100 proteins are small calcium binding proteins with high structural homology. Several members of the family have been shown to interact with RACE in vitro or in cell-based assays. Interestingly, many RAGE ligands appear to interact with distinct domains of the extracellular portion of RAGE and to trigger various cellular effects. In this review, we summarize the modes of SIN protein-RAGE interaction with regard to their cellular functions. (C) 2008 Elsevier B.V. All rights reserved.
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