Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 12, Pages 1828-1836Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2009.11.001
Keywords
TRIM24; Androgen receptor; Prostate cancer; BRD7
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Mitsubishi Pharma Sources of Funding
- Cell Science Research Foundation
- Uehara Memorial Foundation
- Research Foundation Ituu Laboratory
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The androgen receptor (AR) is a ligand-dependent transcription factor that belongs to the family of nuclear receptors, and its activity is regulated by numerous AR coregulators. AR plays an important role in prostate development and cancer. In this study, we found that TRIM24/transcriptional intermediary factor lot (T1F1 alpha), which is known as a ligand-dependent nuclear receptor co-regulator, interacts with AR and enhances transcriptional activity of AR by dihydrotestosterone in prostate cancer cells. We showed that TRIM24 functionally interacts with TIP60, which acts as a coactivator of AR and synergizes with TIP60 in the transactivation of AR. We also showed that TRIM24 binds to bromodomain containing 7 (BRD7), which can negatively regulate cell proliferation and growth. A luciferase assay indicated that BRD7 represses the AR transactivation activity upregulated by TRIM24. These findings indicate that TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7. (C) 2009 Elsevier B.V. All rights reserved.
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