Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 6, Pages 941-946Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2008.10.008
Keywords
Sarcoplasmic reticulum; Ca2+-pump; Ca2+-ATPase; Muscle contraction; Crystal structure; Ion transport
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Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a > 10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so. (C) 2008 Elsevier B.V. All rights reserved.
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