Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 9, Pages 1461-1464Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2008.12.023
Keywords
Autophagy; Antigen presentation; B cell; Dendritic cell; Immunity; Infection; Monocyte; Macrophage; Neutrophil; Phagocytosis; Reticulocyte; T cell
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Funding
- Swiss National Science Foundation [310000-107526, 310000-112078]
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Autophagy is a conserved proteolytic mechanism that degrades cytoplasmic material including cell organelles. The importance of autophagy for cell homeostasis and survival has long been appreciated. Recent data suggest that autophagy is also involved in non-metabolic functions that particularly concern blood cells. Here, we review these findings, which point to an important role of autophagy in several cellular functions related to host defense. (C) 2009 Elsevier B.V. All rights reserved.
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