4.5 Review

Autophagy in cells of the blood

Journal

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 9, Pages 1461-1464

Publisher

ELSEVIER
DOI: 10.1016/j.bbamcr.2008.12.023

Keywords

Autophagy; Antigen presentation; B cell; Dendritic cell; Immunity; Infection; Monocyte; Macrophage; Neutrophil; Phagocytosis; Reticulocyte; T cell

Funding

  1. Swiss National Science Foundation [310000-107526, 310000-112078]

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Autophagy is a conserved proteolytic mechanism that degrades cytoplasmic material including cell organelles. The importance of autophagy for cell homeostasis and survival has long been appreciated. Recent data suggest that autophagy is also involved in non-metabolic functions that particularly concern blood cells. Here, we review these findings, which point to an important role of autophagy in several cellular functions related to host defense. (C) 2009 Elsevier B.V. All rights reserved.

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