Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 1, Pages 54-59Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00156-8
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Although the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor cells by inciting phenotypic and genomic changes in the epithelial cells. The oncogenic action of distinctive stromal components has been demonstrated through a variety of approaches, which provide clues about the cellular pathways involved.
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