Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 20, Issue 5, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.20.5.050504
Keywords
photoacoustics; imaging; tomography; lymph node; cancer; lipid; hemoglobin; multiwavelength; metastasis
Funding
- King's College London
- University College London Comprehensive Cancer Imaging Centre, Cancer Research UK & Engineering and Physical Sciences Research Council,
- Medical Research Council
- Department of Health, UK
- European Union project FAMOS (FP7 ICT) [317744]
- EPSRC [EP/L002019/1, EP/H005536/1] Funding Source: UKRI
- Cancer Research UK [16463] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/L002019/1, EP/H005536/1] Funding Source: researchfish
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Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of ex vivo samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
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