Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1783, Issue 11, Pages 2061-2079Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2008.07.022
Keywords
Genome organization; Nuclear structure; Fluorescence microscopy; Macromolecular dynamics and interactions; Diffusion
Categories
Funding
- DFG [Ri 828/5-3]
- Christiane Nusslein-Volhard Foundation
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The cell needs to stably maintain its genome and protect it from uncontrolled modifications that would compromise its function. At the same time, the genome has to be a plastic structure that can dynamically (re) organize to allow the cell to adopt different functional states. These dynamics occur on the nanometer to micrometer length scale, i.e. ranging from the level of single proteins up to that of whole chromosomes, and on a microsecond to hour time scale. Here, we review different contributions to the dynamic features of the genome, describe how they are determined experimentally, and discuss the results of these measurements in terms of how the requirements for stability and plasticity are accommodated with specific activities in the nucleus. (c) 2008 Elsevier B.V. All rights reserved.
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