Journal
MECHANISMS OF DEVELOPMENT
Volume 100, Issue 2, Pages 263-273Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(00)00535-9
Keywords
Xenopus; bone morphogenetic proteins; embryogenesis; cardiogenesis; cardia bifida; Nkx2-5; GATA-4; GATA-5; GATA-6; troponin C; Smad6; endoderm; myocardium
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Funding
- NICHD NIH HHS [HD01167] Funding Source: Medline
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To examine potential roles for bone morphogenetic proteins (BMPs) in cardiogenesis, we used intracellular BMP inhibitors to disrupt this signaling cascade in Xenopus embryos. BMP-deficient embryos showed endodermal defects, a reduction in cardiac muscle-specific gene expression, a decrease in the number of cardiomyoctes and cardia bifida. Early expression of markers of endodermal and precardiac fate, however, was not perturbed. Heart defects were observed even when BMP signal transduction was blocked only in cells that contribute primarily to endodermal, and not cardiac fates, suggesting a non-cell autonomous function. Our results suggest that BMPs are not required for expression of early transcriptional regulators of cardiac fate but are essential for migration and/or fusion of the heart primordia and cardiomyocyte differentiation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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