Journal
PHARMACOLOGY & THERAPEUTICS
Volume 89, Issue 2, Pages 187-206Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0163-7258(00)00114-5
Keywords
cardiovascular disease; reactive oxygen species; oxidants; antioxidants; nitric oxide; peroxynitrite
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Funding
- NHLBI NIH HHS [HL63067, HL59791] Funding Source: Medline
- NIDDK NIH HHS [DK55053] Funding Source: Medline
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Despite some recent declines, cardiovascular disease (CVD) remains the major cause of death in the United States and worldwide. Most recent advances in the treatment of CVD states have been produced by inhibition of mechanisms involved in disease progress. Many studies conducted in the last decade have illustrated increased biological oxidative pathways during CVD in animals and humans. Thus, increased production of reactive oxygen species may be a unifying mechanism in CVD progression, and antioxidants may have therapeutic value in this setting. In this review we address the following questions: Do oxidative mechanisms play a role in CVD? Where do the oxidants come from? What are the relevant oxidative events? What are the therapeutic implications? (C) 2001 Elsevier Science Inc, All rights reserved.
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