Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 3, Pages 1165-1171Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.3.1165-1171.2001
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Funding
- NIAID NIH HHS [AI24755, R37 AI024755, AI31783, R01 AI031783, AI39420, R01 AI039420, P30 AI028691] Funding Source: Medline
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Human immunodeficiency virus (HIV-1) envelope glycoprotein subunits, such as the gp120 exterior glycoprotein, typically elicit antibodies that neutralize T-cell-line-adapted (TCLA), but not primary, clinical isolates of HIV-1. Here we compare the immunogenicity of gp120 and soluble stabilized trimers, which were designed to resemble the functional envelope glycoprotein oligomers of primary and TCLA HIV-1 strains. For both primary and TCLA virus proteins, soluble stabilized trimers generated neutralizing antibody responses more efficiently than gp120 did. Trimers derived from a primary isolate elicited antibodies that neutralized primary and TCLA HIV-1 strains. By contrast, trimers derived from a TCLA isolate generated antibodies that neutralized only the homologous TCLA virus. Thus, soluble stabilized envelope glycoprotein trimers derived from primary HIV-1 isolates represent defined immunogens capable of eliciting neutralizing antibodies that are active against clinically relevant HIV-1 strains.
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