Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1832, Issue 7, Pages 866-875Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2012.11.022
Keywords
Extracellular matrix; Collagen; Elastin; Self-assembly; Tensile strength; Elastic modulus
Funding
- Heart and Stroke Foundation of Ontario [T6725]
- Canadian Institutes of Health Research [MOP84496]
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The extracellular matrix is an integral and dynamic component of all tissues. Macromolecular compositions and structural architectures of the matrix are tissue-specific and typically are strongly influenced by the magnitude and direction of biomechanical forces experienced as part of normal tissue function. Fibrous extracellular networks of collagen and elastin provide the dominant response to tissue mechanical forces. These matrix proteins enable tissues to withstand high tensile and repetitive stresses without plastic deformation or rupture. Here we provide an overview of the hierarchical molecular and supramolecular assembly of collagens and elastic fibers, and review their capacity for mechanical behavior in response to force. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease. (C) 2012 Elsevier B.V. All rights reserved.
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