Journal
AMERICAN JOURNAL OF HUMAN GENETICS
Volume 68, Issue 2, Pages 533-536Publisher
CELL PRESS
DOI: 10.1086/318190
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We measured the proportion of mutant mtDNA (mutation load) in 82 primary oocytes from a woman who harbored the A3243G mtDNA mutation. The frequency distribution of mutation load indicates that random drift is the principal mechanism that determines the level of mutant mtDNA within individual oocytes.
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