Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1812, Issue 12, Pages 1630-1639Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2011.08.012
Keywords
Aging; Amyloid; Brain; Dementia; Alzheimer's disease; Mitochondria
Funding
- Morgan Family Foundation
- [P30AG035982]
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The relationship between brain aging and Alzheimer's disease (AD) is contentious. One view holds AD results when brain aging surpasses a threshold. The other view postulates AD is not a consequence of brain aging. This review discusses this conundrum from the perspective of different investigative lines that have tried to address. it, as well as from the perspective of the mitochondrion, an organelle that appears to play a role in both AD and brain aging. Specific issues addressed include the question of whether AD and brain aging should be conceptually lumped or split, the extent to which AD and brain aging potentially share common molecular mechanisms, whether beta amyloid should be primarily considered a marker of AD or simply brain aging, and the definition of AD itself. (C) 2011 Elsevier B.V. All rights reserved.
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