Journal
ANALYST
Volume 140, Issue 17, Pages 5860-5863Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an01203a
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Funding
- CORSAIRE Metabolomics platform (Biogenouest network)
- Swiss National Science Foundation (SNSF)
- Ecole Polytechnique Federale de Lausanne (EPFL)
- Swiss Commission for Technology and Innovation (CTI)
- CNRS
- European Research Council (ERC) [339754]
- Bruker BioSpin
- MetaboHUB [ANR-11-INBS-0010]
- Eranet-EraSysBio+ FRuit Integrative Modelling project
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Natural abundance C-13 NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.
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