Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 11, Issue 1, Pages 120-124Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00168-8
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The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.
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