Journal
JOURNAL OF NATURAL PRODUCTS
Volume 64, Issue 2, Pages 262-264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np000368+
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Funding
- ARRA NIH HHS [RA2 A140715] Funding Source: Medline
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Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 mug/mL (SDB) and 3.1 mug/mL (RPMI) for 3, and 25 mug/mL (SDB) and 6.25 mug/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 mug/mL.
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