Journal
FEBS LETTERS
Volume 489, Issue 2-3, Pages 139-143Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02095-6
Keywords
astrocyte differentiation; bone morphogenetic protein; crosstalk; interleukin-6 family of cytokine; Smad; STAT3
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We here show that hone morphogenetic protein (BMP) 7 acted in synergy with the distinct type of cytokines, leukemia inhibitory factor (LIF) and interleukin (IL) 6 that are in the IL-6 family, to induce astrocyte differentiation from neuroepithelial cells as assessed by expression of glial fibrillary acidic protein (GFAP), In this synergistic action, transcription factors, Smads and STAT3 (for signal transducer and activator of transcription 3) activated by respective group of cytokines, as well as a transcriptional coactivator p300 were essential. Taken together with our previous finding that the synergistic astrocyte induction by BMP2 and LIF is attributed to the complex formation of Smads and STAT3 bridged by p300, it is conceivable that this complex formation is a mechanism utilized in common by two different types of cytokines belonging to the BMP and IL-6 families in order to synergistically induce astrocyte differentiation. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.
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