Journal
SCIENCE
Volume 291, Issue 5505, Pages 878-881Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.291.5505.878
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Funding
- NIGMS NIH HHS [GM20565, 5 RO1 GM40266] Funding Source: Medline
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Biofilms are formed by the aggregation of microorganisms into multicellular structures that adhere to surfaces. Here we show that bakers' yeast Saccharomyces cerevisiae can initiate biofilm formation. When grown in Low-glucose medium, the yeast cells adhered avidly to a number of plastic surfaces. On semi-solid (0.3% agar) medium they formed mats: complex multicellular structures composed of yeast-form cells. Both attachment to plastic and mat formation require Flo11p, a member of a Large family of fungal cell surface glycoproteins involved in adherence. The ability to study biofilm formation in a tractable genetic system may facilitate the identification of new targets for antifungal therapy.
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