Journal
FEBS LETTERS
Volume 489, Issue 2-3, Pages 149-153Publisher
WILEY
DOI: 10.1016/S0014-5793(01)02089-0
Keywords
AMP-activated protein kinase; apoptosis; ceramide; extracellular signal-regulated kinase; astrocyte
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Fatty acids induce apoptosis in primary astrocytes by enhancing ceramide synthesis de novo, The possible role of the AR IP-activated protein kinase (AMPK) in the control of apoptosis was studied in this model. Long-term stimulation of AMPK with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) prevented apoptosis, AICAR blunted fatty acid-mediated induction of serine palmitoyltransferase and ceramide synthesis de novo, without affecting fatty acid synthesis and oxidation. Prevention of ceramide accumulation by AICAR led to a concomitant blockade of the Raf-1/extracellular signal-regulated kinase cascade, which selectively mediates fatty acid-induced apoptosis, Data indicate that AMPK may protect cells from apoptosis induced by stress stimuli. (C) 2001 Federation of European Bicohemical Societies. Published by Elsevier Science B.V. All rights reserved.
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