Journal
TETRAHEDRON LETTERS
Volume 42, Issue 6, Pages 1123-1126Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(00)02203-6
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When compared to an equivalent amine concentration (N-acetylethylene diamine, 64 equivalents), the initial rate of a simple deacylation reaction in water was found to be greatly enhanced when using a PAMAM dendrimer with 64 terminal amine groups. This increase in initial late is largely due to the hydrophobic binding of the substrate within the outer region of the dendrimer. As a consequence of this binding, the substrate is held in close proximity to the reactive amine groups on the surface of the dendrimer. It is this increase in effective molarity that results in an increase in the observed initial rate. (C) 2001 Elsevier Science Ltd. All rights reserved.
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