Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1792, Issue 12, Pages 1138-1144Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2008.11.011
Keywords
Mitochondrial dynamics; Dnm1; Drp1; Fis1; Dynamin-related protein
Funding
- NIH [5R01GM062942, 1F32GM078749]
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Mitochondria are highly dynamic organelles that continuously divide and fuse. These dynamic processes regulate the size, shape, and distribution of the mitochondrial network. In addition, mitochondrial division and fusion play critical roles in cell physiology. This review will focus on the dynamic process of mitochondrial division, which is highly conserved from yeast to humans. We will discuss what is known about how the essential components of the division machinery function to mediate mitochondrial division and then focus on proteins that have been implicated in division but whose functions remain unclear. We will then briefly discuss the cellular functions of mitochondrial division and the problems that arise when division is disrupted. Published by Elsevier B.V.
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