Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1792, Issue 8, Pages 757-765Publisher
ELSEVIER
DOI: 10.1016/j.bbadis.2009.05.004
Keywords
Osteoclast; Osteopetrosis; Heterogeneity; Intramembranous bone; Endochondral bone; Osteoclast subset
Funding
- Arthritis Research Campaign [17440]
- Chief Scientist Office [CZB/4/495] Funding Source: researchfish
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The multinucleated osteoclast has a unique function: degradation of mineralized tissues. It is generally taken that all osteoclasts are alike, independent of the skeletal site where they exert their activity. Recent data, however, question this view as they show that osteoclasts at different bony sites appear to differ, for example in the machinery responsible for resorption. Support for the notion that there may be heterogeneity in osteoclasts is obtained from studies in which osteoclast activity is inhibited and from observations in osteopetrosis and inflammatory bone conditions. In this review we discuss the available evidence and propose the existence of bone-site-specific osteoclast heterogeneity. (C) 2009 Elsevier B.V. All rights reserved.
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