Journal
ORGANIC LETTERS
Volume 3, Issue 3, Pages 485-487Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol007009q
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Funding
- NCRR NIH HHS [RR02002] Funding Source: Medline
- NIGMS NIH HHS [GM 04842] Funding Source: Medline
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[GRAPHICS] A short and efficient asymmetric total synthesis of the title compound 1, which is an important neurotransmitter, has been achieved. The synthesis features a metal promoted, enantioselective ene reaction that provides entry into the kainic acid ring system from very simple precursors. Moreover, the zirconium-mediated Strecker reaction, which represents an outgrowth of earlier amide-to imine methodology developed in our laboratory, demonstrates remarkable chemoselectivity and stereoselectivity.
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