Journal
TETRAHEDRON
Volume 57, Issue 7, Pages 1213-1218Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)01109-1
Keywords
asymmetric synthesis; optical resolution; reduction; antimalarial compounds
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The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution. (C) 2001 Elsevier Science Ltd. All rights reserved.
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