Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1841, Issue 8, Pages 1060-1084Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2014.01.009
Keywords
Glycerolipid; Lipase; Metabolism; Inhibitor; Phospholipase; Autotaxin; Lipid kinase; Lipin; Fatty acyltransferase
Funding
- McDonnell Foundation for Brain Cancer Research, Bixler-Johnson-Mayes Endowed Chair
- NIH [U54 MH084659]
- NIEHS [P01-ES013125]
- William K. Warren Jr. Chair in Medicine
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Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields-ranging from neuroscience and cancer to diabetes and obesity have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. This article is part of a Special Issue entitled Tools to study lipid functions. (C) 2014 Elsevier B.V. All rights reserved.
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