Journal
JOURNAL OF BIOTECHNOLOGY
Volume 85, Issue 2, Pages 149-173Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-1656(00)00361-8
Keywords
process monitoring; state estimation; structured models; metabolic flux analysis; expert systems; pattern recognition
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The paper gives a review on the recent development of bioprocess engineering. It includes monitoring of product formation processes by flow injection analysis, Various types of chromatographic and spectroscopic methods as well as by biosensors. The evaluation of mycelial morphology and physiology by digital image analysis is discussed also. It deals with advanced control of indirectly evaluated process variables by means of state estimation/observer, with the use of structured and hybrid models, expert systems and pattern recognition for process optimization and gives a short report on the state of the art of metabolic flux analysis and metabolic engineering. (C) 2001 Elsevier Science B.V. All rights reserved.
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