Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1831, Issue 3, Pages 575-581Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2012.09.014
Keywords
Phosphatidic acid; Phosphatidic acid phosphatase; Lipin; Nucleus; Nuclear envelope; Nuclear lipids
Funding
- Medical Research Council [G0701446]
- Medical Research Council [G0701446] Funding Source: researchfish
- MRC [G0701446] Funding Source: UKRI
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Phospholipids play important roles in nuclear function as dynamic building blocks for the biogenesis of the nuclear membrane, as well as signals by which the nucleus communicates with other organelles, and regulate a variety of nuclear events. The mechanisms underlying the nuclear roles of phospholipids remain poorly understood. Lipins represent a family of phosphatidic acid (PA) phosphatases that are conserved from yeasts to humans and perform essential functions in lipid metabolism. Several studies have identified key roles for lipins and their regulators in nuclear envelope organization, gene expression and the maintenance of lipid homeostasis in yeast and metazoans. This review discusses recent advances in understanding the roles of lipins in nuclear structure and function. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism. (C) 2012 Elsevier B.V. All rights reserved.
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