Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1831, Issue 3, Pages 652-662Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2012.08.019
Keywords
N-acylphosphatidylethanolamine; N-acylphosphatidylethanolamine-hydrolyzing phospholipase D; N-acyltransferase; Phospholipid; N-acylplasmenylethanolamine; Food intake
Funding
- Carlsberg Foundation
- Danish Council for Independent Research, Natural Sciences
- Novo Nordisk Foundation
- UNIK program Food
- Fitness and Pharma for Health and Disease
- Danish Ministry of Science, Technology, and Innovation
- Novo Nordisk Fonden [NNF11OC1015218] Funding Source: researchfish
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N-acylphosphatidylethanolamine (NAPE) and N-acylplasmenylethanolamine (pNAPE) are widely found phospholipids, and they are precursors for N-acylethanolamines, a group of compounds that has a variety of biological effects and encompasses the endocannabinoid anandamide. NAPE and pNAPE are synthesized by the transfer of an acyl chain from a donor phospholipid, to the amine in phosphatidylethanolamine or plasmenylethanolamine. NAPE has been reported to stabilize model membranes during brain ischemia, and to modulate food intake in rodents, thus having bioactive effects besides its precursor role. This paper reviews the metabolism, occurrence and assay of NAPE and pNAPE, and discusses the putative biological functions in mammals of these phospholipids. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism. (C) 2012 Elsevier B.V. All rights reserved.
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