Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 531, Issue 1, Pages 165-170Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1111/j.1469-7793.2001.0165j.x
Keywords
-
Categories
Ask authors/readers for more resources
1.Our goal was to describe the in situ responses in rats of single-unit carotid body chemoreceptors to changes in arterial P-O2 and P-CO2. We identified single-unit carotid chemoreceptor activity in male, adult Sprague-Dawley rats by their rapid responses to I.V. NaCN (20 mug) and transient (10 s) asphyxia. 2. Single-unit chemoreceptor responses to isocapnic changes in oxygenation within the arterial oxygen pressure range 34-114 mmHg were described by the power function: f(dis) = 74010(P-a,P-O2)(-2.5); (r(2) = 0.6), where f(dis) is the discharge frequency (spikes s-(1)), P-a,P-O2 is the arterial oxygen partial pressure (mmHg) and r2 is the correlation coefficient. 3. The responses to iso-oxic changes in CO2, assumed to be linear, had a slope of 0.089 spikes s(-1) (mmHg P-a,P-CO2)(-1)(r(2) = 0.7). 4. We conclude that carotid body chemoreceptors in adult rats have responses to changes in P-a,P-O2 and P-a,P-CO2 similar to those of other species.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available