Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1831, Issue 9, Pages 1475-1485Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2013.06.001
Keywords
Glycolipid; Sphingolipid; Glucosylceramide; Glucosylation; Cholesterylglucoside; Phosphatidylglucoside
Funding
- RIKEN Brain Science Institute
- RIKEN Special Postdoctoral Researchers Program
- Research Activity Start-up
- Scientific Research on Innovative Areas Machineries of bioactive lipids in homeostasis and diseases
- Deciphering sugar chain-based signals regulating integrative neuronal functions from the Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [24770198] Funding Source: KAKEN
Ask authors/readers for more resources
Ceramide, cholesterol, and phosphatidic acid are major basic structures for cell membrane lipids. These lipids are modified with glucose to generate glucosylceramide (GlcCer), cholesterylglucoside (ChlGlc), and phosphatidylglucoside (PtdGlc), respectively. Glucosylation dramatically changes the functional properties of lipids. For instance, ceramide acts as a strong tumor suppressor that causes apoptosis and cell cycle arrest, while GlcCer has an opposite effect, downregulating ceramide activities. All glucosylated lipids are enriched in lipid rafts or microdomains and play fundamental roles in a variety of cellular processes. In this review, we discuss the biological functions and metabolism of these three glucosylated lipids. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
