Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1831, Issue 6, Pages 1113-1123Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2013.01.017
Keywords
Hepatic lipase; Triacylglycerol; VLDL; apoB; Fatty acid oxidation; Endoplasmic reticulum
Funding
- Heart and Stroke Foundation of Alberta
- Heart and Stroke Foundation of Northwest Territories
- Heart and Stroke Foundation of Nunavut
- Canadian Institutes of Health Research
- University of Alberta Faculty of Medicine and Dentistry
- Heart and Stroke of Canada postdoctoral fellowship
- Alexander Graham Bell Canada from the Natural Sciences and Engineering Research Council of Canada
- Walter H. Johns fellowship from the University of Alberta
- Women and Children Health Research Institute
Ask authors/readers for more resources
Hepatic triacylglycerol levels are governed through synthesis, degradation and export of this lipid. Here we demonstrate that enforced expression of hepatic lipase in the endoplasmic reticulum in McArdle RH7777 hepatocytes resulted in a significant decrease in the incorporation of fatty acids into cellular triacylglycerol and cholesteryl ester accompanied by attenuation of secretion of apolipoprotein B-containing lipoproteins. Hepatic lipase-mediated depletion of intracellular lipid storage increased the expression of peroxisome proliferator-activated receptor alpha and its target genes and augmented oxidation of fatty acids. These data show that I) hepatic lipase is active in the endoplasmic reticulum and 2) intracellular hepatic lipase modulates cellular lipid metabolism and lipoprotein secretion. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
