Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 281, Issue 1, Pages 32-36Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/bbrc.2001.4289
Keywords
Tc-99m-labeled dendritic porphyrin; scintiimaging; photodynamic therapy; photodynamic diagnosis
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Funding
- NCI NIH HHS [P01 CA48735] Funding Source: Medline
- PHS HHS [R01 51802] Funding Source: Medline
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We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeIed them with Tc-99m. These Tc-99m-labeled porphyrins were administered to C-6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications. (C) 2001 Academic Press.
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