Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1821, Issue 8, Pages 1050-1058Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2012.01.004
Keywords
Endoplasmic reticulum; Glycosylphosphatidylinositol; Golgi apparatus; Lipid raft; Sorting; Trafficking
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Naito Foundation
- Senri Life Science Foundation
- Osaka University Global COE Program
- Grants-in-Aid for Scientific Research [21247018] Funding Source: KAKEN
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Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational modification in eukaryotes. GPI is synthesized and transferred to proteins in the endoplasmic reticulum. GPI-anchored proteins are then transported from the endoplasmic reticulum to the plasma membrane through the Golgi apparatus. GPI-anchor functions as a sorting signal for transport of GPI-anchored proteins in the secretory and endocytic pathways. After GPI attachment to proteins, the structure of the GPI-anchor is remodeled, which regulates the trafficking and localization of GPI-anchored proteins. Recently, genes required for GPI remodeling were identified in yeast and mammalian cells. Here, we describe the structural remodeling and function of GPI-anchors, and discuss how GPI-anchors regulate protein sorting, trafficking, and dynamics. This article is part of a Special Issue entitled Lipids and Vesicular Transport. (C) 2012 Elsevier B.V. All rights reserved.
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