Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1821, Issue 1, Pages 241-247Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2011.06.014
Keywords
Vitamin A; Mitochondrion; Protein kinase C delta; Energy homeostasis
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The protein kinase C delta signalosome modulates the generation of acetyl-Coenzyme A from glycolytic sources. This module is composed of four interlinked components: PKC delta, the signal adapter p66Shc, cytochrome c, and vitamin A. It resides in the intermembrane space of mitochondria, and is at the center of a feedback loop that senses upstream the redox balance between oxidized and reduced cytochrome c as a measure of the workload of the respiratory chain, and transmits a forward signal to the pyruvate dehydrogenase complex to adjust the flux of fuel entering the tricarboxylic acid cycle. The novel role of vitamin A as co-activator and potential electron carrier, required for redox activation of PKC delta, is discussed. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism. (C) 2011 Published by Elsevier B.V.
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