Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1821, Issue 5, Pages 747-753Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2011.09.017
Keywords
Lipid signaling; PPAR alpha; Post-translational regulation; Obesity; Fatty liver; Diabetes
Funding
- NIDDK NIH HHS [R01 DK088083, R01 DK088083-02, R01 DK076729, R01 DK076729-04] Funding Source: Medline
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Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has long been categorized as a housekeeping protein, producing fat for storage of energy when nutrients are present in excess. Most previous studies of FAS regulation have focused on the control of gene expression. However, recent findings suggest that hepatic FAS may also be involved in signaling processes that include activation of peroxisome proliferator-activated receptor alpha (PPAR alpha). Moreover, reports of rapid alterations in FAS activity as well as findings of post-translational modifications of the FAS protein support the notion that dynamic events in addition to transcription impact FAS regulation. These results indicate that FAS enzyme activity can impact liver physiology through signaling as well as energy storage and that its regulation may be complex. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease. (C) 2011 Elsevier B.V. All rights reserved.
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