Journal
TETRAHEDRON
Volume 57, Issue 8, Pages 1609-1614Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)01141-8
Keywords
2-arylhydrazono-3-oxopropanal; cinnolines; aryl methyl ketones
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An efficient synthesis of 3-aroylcinnolines starting from the appropriate aryl methyl ketones is described. The latter were converted in two steps to the corresponding 3-oxo-3-aryl-2-arylhydrazonopropanals, which upon acid catalyzed cyclization in cone. sulfuric acid or polyphosphoric acid (PPA) led to the corresponding 3-aroylcinnolines. (C) 2001 Elsevier Science Ltd. All rights reserved.
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