Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 214, Issue 1-2, Pages 21-24Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(00)00626-8
Keywords
nanosuspensions; high concentration; high pressure homogenisation; surfactants
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Nanosuspensions produced by high-pressure homogenisation are a solution for the formulation of poorly soluble drugs with bioavailability problems. The typical solid concentration of the nanosuspensions is 10%. However, to transfer the nanosuspensions to a dry product (e.g. granulation, tablets, pellets), a higher solid content is required to remove less water. Nanosuspensions with 20 and 30%, solid content were produced, the effect of surfactant concentration assessed and their quality (size data) compared with the lower standard concentrations of 1-10% solid. (C) 2001 Elsevier Science B.V. All rights reserved.
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