Enantio- and diastereoselective Michael reactions of silyl enol ethers and chalcones by catalysis using a chiral quaternary ammonium salt

[GRAPHICS] N-(9-Anthracenylmethyl)dihydrocinchonidinium bromide (1) is an effective catalyst for enantioselective Michael additions to chalcones, as shown in the above example, using toluene/50% aqueous KOH biphasic conditions at -20 degreesC.