4.8 Article

Synthesis of a conformationally restricted substrate analogue of siderophore biosynthetases

Journal

ORGANIC LETTERS
Volume 3, Issue 4, Pages 519-521

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol006813+

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[GRAPHICS] A conformationally restricted analogue (5) of N-omega-acetyl-N-omega-hydroxyornithine and lysine was synthesized. The synthesis features an efficient acylnitroso hetero-Diels-Alder cycloadduct (1) ring opening with palladium(0) and methylnitroacetate.

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