Journal
SCIENCE
Volume 291, Issue 5508, Pages 1547-1550Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1056866
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Funding
- NIGMS NIH HHS [R01 GM059363-02, R01 GM059363] Funding Source: Medline
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Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase, Karyoplasts (acentrosomal cells) entered and completed mitosis, However, postmitotic karyoplasts arrested before S phase, whereas adjacent control cells divided repeatedly. Postmitotic karyoplasts assembled a microtubule-organizing center containing gamma -tubulin and pericentrin, but did not regenerate centrioles. These observations reveal the existence of an activity associated with core centrosomal structures-distinct from elements of the microtubule-organizing center-that is required for the somatic cell cycle to progress through G(1) into S phase. Once the cell is in S phase, these core structures are not needed for the G(2)-M phase transition.
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