Journal
SCIENCE
Volume 291, Issue 5508, Pages 1541-1544Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1056600
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Funding
- NIAID NIH HHS [R01 AI033608] Funding Source: Medline
- PHS HHS [33890] Funding Source: Medline
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Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which receptor editing shapes the normal antibody repertoire, we generated an immunoglobulin kappa polymorphism that facilitates the detection of;editing of immunoglobulin light chains in vivo. We found that B cells are targeted for editing during a 2-hour delay in development at the pre-BII cell stage, and that about 25% of all antibody molecules are produced by gene replacement. These results suggest that receptor editing represents a major force in shaping the antibody repertoire.
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