Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
Volume 356, Issue 1406, Pages 213-227Publisher
ROYAL SOC LONDON
DOI: 10.1098/rstb.2000.0767
Keywords
tau protein; Alzheimer's disease; Pick's disease; alpha-synuclein; Lewy body diseases; multiple system atrophy
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The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule-associated protein tau or the protein alpha -synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutation in the alpha -synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and alpha -synuclein can cause neurodegeneration.
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