Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1781, Issue 9, Pages 435-441Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2008.07.001
Keywords
lysophospholipid; S1P; development; vascular; neural; maternal : fetal interface; decidualization
Funding
- Intramural NIH HHS [Z01 DK056014-01, Z01 DK056016-01, Z01 DK056018-01, Z01 DK056019-01, Z01 DK056017-01, Z01 DK056015-01] Funding Source: Medline
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Sphingosine-1-phosphate (SIP) was first identified as a lysophospholipid metabolite whose formation is required for the irreversible degradation of sphingolipids. Years later, it was discovered that S1P is a bioactive lipid that provokes varied cell responses by acting through cell-surface receptors to drive cell signaling. More recent findings in model organisms have now established that S1P metabolism and signaling are integrated into many physiological systems. We describe here the surprising breadth of function of S1P in mammalian development and the underlying biologic processes that S1P regulates. (c) 2008 Elsevier B.V. All rights reserved.
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