Journal
LEUKEMIA & LYMPHOMA
Volume 41, Issue 1-2, Pages 213-215Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10428190109057974
Keywords
fludarabine; gonadotrophin releasing hormone; chronic lymphocytic leukaemia; pituitary-testicular axis
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We describe a case of a 47 year old man with CLL who was treated with 7 courses of fludarabine with simultaneous suppression or his pituitary-testicular axis (P-T) with Gonadotrophin releasing hormone (GnRH) and replacement treatment with testosterone. Despite initial gonadal damage as evident by endocrine and sperm studies. testicular recovery was observed 11 months post treatment. Although spontaneous recovery cannot be ruled out. continous treatment with GnRH and testosterone may play a crucial role protecting the gonads from the cytotoxic effects of the chemotherapeutic agents.
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