Journal
NEPHRON
Volume 87, Issue 3, Pages 215-222Publisher
KARGER
DOI: 10.1159/000045918
Keywords
erythropoietin; hematopoiesis; second messengers; JAK2; intracellular calcium; cytokine receptors
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Funding
- NCRR NIH HHS [M01 RR10732] Funding Source: Medline
- NHLBI NIH HHS [HL 58672] Funding Source: Medline
- NIDDK NIH HHS [DK 46778] Funding Source: Medline
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Erythropoietin is an obligatory growth factor for red blood cell production. The receptor for erythropoietin contains a single membrane-spanning domain with no intrinsic tyrosine kinase motifs. On binding to erythropoietin, the receptor dimerizes and activates multiple intracellular signaling molecules, including but not limited to JAK2, STAT5, PI 3-kinase, IRS-2, RAS, and Ca2+ channels. This review focuses on cytoplasmic signaling cascades involved in erythropoietin action. Copyright (C) 2002 S. Karger AG, Basel.
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