Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 6, Issue 3, Pages 209-226Publisher
SPRINGER
DOI: 10.1007/s007750100210
Keywords
iron-sulfur cluster; radical generation; adenosylmethionine; protein radicals
Funding
- NIGMS NIH HHS [R01 GM054608, GM54608, F32 GM20315] Funding Source: Medline
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Iron-sulfur clusters are widespread in biological systems and participate in a broad range of functions. These functions include electron transport, mediation of redox as well as non-redox catalysis, and regulation of gene expression. A new role for iron-sulfur clusters has emerged in recent years as a number of enzymes have been identified that utilize Fe-S clusters and S-adenosylmethionine (AdoMet) to initiate radical catalysis. This Fe-S cluster-mediated radical catalysis includes the generation of stable protein-centered radicals as well as generation of substrate radical intermediates, with evidence suggesting a common mechanism involving an intermediate adenosyl radical. Although the mechanism of generation of the adenosyl radical intermediate is currently not well understood, it likely represents novel chemistry for iron-sulfur clusters. The purpose of this review is to present the current state of knowledge of this newly emerging group of Fe-S/AdoMet enzymes.
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