Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1840, Issue 4, Pages 1303-1312Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2013.09.019
Keywords
Mitochondrial dysfunction; Insulin resistance; Type 2 diabetes; Lipid accumulation; Reactive oxygen species; Inflammation
Categories
Funding
- NHMRC [APP1027227, 1030474]
- Diabetes Australia Research Trust
- Central Research Grant Scheme of Deakin University
- Deakin University Molecular and Medical Research Strategic Research Centre
Ask authors/readers for more resources
Background: The prevalence of type 2 diabetes is rapidly increasing world-wide and insulin resistance is central to the aetiology of this disease. The biology underpinning the development of insulin resistance is not completely understood and the role of impaired mitochondrial function in the development of insulin resistance is controversial. Scope of review: This review will provide an overview of the major processes regulated by mitochondria, before examining the evidence that has investigated the relationship between mitochondrial function and insulin action. Further considerations aimed at clarifying some controversies surrounding this issue will also be proposed. Major conclusions: Controversy on this issue is fuelled by our lack of understanding of some of the basic biological interactions between mitochondria and insulin regulated processes in the context of insults thought to induce insulin resistance. Aspects that have not yet been considered are tissue/cell type specific responses, mitochondrial responses to site-specific impairments in mitochondrial function and as yet uncharacterised retrograde signalling from mitochondria. General significance: Further investigation of the relationship between mitochondria and insulin action could reveal novel mechanisms contributing to insulin resistance in specific patient subsets. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available