Fabrication of organic electrochemical transistor arrays for biosensing

Background: Organic electrochemical transistors (OECT) have been used as various types of biosensors with very high sensitivity. The OECTs show advantages of easy fabrication, low operational voltage, excellent flexibility and biocompatibility. Methods: OECT arrays based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were fabricated in poly(ethylene glycol) (PEG) microwells by physical delamination. Results: The OECTs show fast response time, stable channel current and excellent transistor characteristics. The PEG microwells can be used to trap cells on top of the OECTs, which will be important for the application of the OECT arrays as cell-based biosensors. General significance: This technique provides a feasible way for high-throughput cell analysis based on transistor arrays. This article is part of a Special Issue entitled Organic Bioelectronics Novel Applications in Biomedicine. (C) 2012 Elsevier B.V. All rights reserved.