Journal
JOURNAL OF NEUROCHEMISTRY
Volume 76, Issue 5, Pages 1585-1588Publisher
WILEY
DOI: 10.1046/j.1471-4159.2001.00201.x
Keywords
A2a receptor; adenylyl cyclase; D1 receptor; G alpha(olf); G alpha(s); striatum
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In the brain, dopamine and adenosine stimulate cyclic AMP (cAMP) production through D1 and A2a receptors, respectively. Using mutant mice deficient in the olfactory isoform of the stimulatory GTP-binding protein alpha subunit, G alpha (olf), we demonstrate here the obligatory role of this protein in the adenylyl cyclase responses to dopamine and adenosine in the caudate putamen. Responses to dopamine were also dramatically decreased in the nucleus accumbens but remained unaffected in the prefrontal cortex. Moreover, in the caudate putamen of mice heterozygous for the mutation, the amounts of G alpha (olf) were half of the normal levels, and the efficacy of dopamine- and CGS 21680 A(2) agonist-stimulated cAMP production was decreased. Together, these results identify G alpha (olf) as a critical parameter in the responses to dopamine and adenosine in the basal ganglia.
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