Journal
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
Volume 11, Issue 1, Pages 117-125Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2015.2055
Keywords
Graphene Oxide; Polyvinylpyrrolidone; Chlorin e6; RGD; Photodynamic Therapy
Funding
- MOST [2010CB933901, 2011CB933100, 2013CB733802]
- NSFC [81171399, 81101077]
- National Significant New Drugs Creation Program [2012ZX09505-001-001]
- Jiangsu Province Science and Technology Foundation [BE2012622, BK2011166, BL2012031]
- Health Ministry of Jiangsu Province Fund [RC2011095, H201028]
- Public service platform for Science and technology infrastructure construction project of Jiangsu Province [BM2012066]
- Intramural Research Program (IRP), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
Ask authors/readers for more resources
In this study, using chemically reduced graphene oxide (GO) as a model nanocarbon, we successfully developed a facile surface-functionalization strategy of nanocarbons to allow both biocompatibility and receptor targeted drug delivery. Polyvinylpyrrolidone (PVP) coating improves aqueous dispersibility and biocompatibility of GO, and provides anchoring sites for ACDCRGDCFCG peptide (RGD4C). Aromatic photosensitizer chlorin e6 (Ce6) can be effectively loaded into the rGO-PVP-RGD system via hydrophobic interactions and pi-pi stacking. The nanodelivery system can significantly increase the accumulation of Ce6 in tumor cells and lead to an improved photodynamic therapy (PDT) efficacy as compared to Ce6 alone. The facile surface functionalization strategy can be applied to other nanomaterials such as carbon nanotubes, and inorganic nanomaterials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
